Overall Cdk activity modulates the DNA damage response in mammalian cells

In response to DNA damage, cells activate a phosphorylation-based signaling cascade known as the DNA damage response (DDR). One of the main outcomes of DDR activation is inhibition of cyclin-dependent kinase (Cdk) activity to restrain cell cycle progression until lesions are healed. Recent studies h...

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Bibliografiske detaljer
Main Authors: Cerqueira, Antonio, Santamaría, David, Martínez-Pastor, Bárbara, Cuadrado, Miriam, Fernández-Capetillo, Oscar, Barbacid, Mariano
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2009
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806328/
https://ncbi.nlm.nih.gov/pubmed/19995934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200903033
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