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Bcl2 Negatively Regulates DNA Double-Strand Break Repair through a Non-Homologous End Joining Pathway
Bcl2 can enhance susceptibility to carcinogenesis but the mechanism(s) remains fragmentary. Here we discovered that Bcl2 suppresses DNA double-strand break (DSB) repair and V(D)J recombination by down-regulating Ku DNA binding activity, which is associated with increased genetic instability. Exposur...
में बचाया:
| मुख्य लेखकों: | , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2008
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2806186/ https://ncbi.nlm.nih.gov/pubmed/18313386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.12.029 |
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