Sildenafil inhibits chronically hypoxic upregulation of canonical transient receptor potential expression in rat pulmonary arterial smooth muscle

In pulmonary arterial smooth muscle cells (PASMCs), Ca(2+) influx through store-operated Ca(2+) channels thought to be composed of canonical transient receptor potential (TRPC) proteins is an important determinant of intracellular free calcium concentration ([Ca(2+)](i)) and pulmonary vascular tone....

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Detalhes bibliográficos
Main Authors: Lu, Wenju, Ran, Pixin, Zhang, Dandan, Peng, Gongyong, Li, Bing, Zhong, Nanshan, Wang, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
Assuntos:
Membrane Transporters, Ion Channels and Pumps
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806156/
https://ncbi.nlm.nih.gov/pubmed/19889962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00629.2008
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