BMP4 Increases Canonical Transient Receptor Potential Protein Expression by Activating p38 MAPK and ERK1/2 Signaling Pathways in Pulmonary Arterial Smooth Muscle Cells

Abnormal bone morphogenetic protein (BMP) signaling has been implicated in the pathogenesis of pulmonary hypertension. We previously found that BMP4 elevated basal intracellular Ca(2+) ([Ca(2+)](i)) concentrations in distal pulmonary arterial smooth muscle cells (PASMCs), attributable in large part...

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Main Authors: Li, Xiaoyan, Lu, Wenju, Fu, Xin, Zhang, Yi, Yang, Kai, Zhong, Nanshan, Ran, Pixin, Wang, Jian
Format: Artigo
Jezik:Inglês
Izdano: American Thoracic Society 2013
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824027/
https://ncbi.nlm.nih.gov/pubmed/23526217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0051OC
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