Sildenafil Inhibits Hypoxia-Induced Transient Receptor Potential Canonical Protein Expression in Pulmonary Arterial Smooth Muscle via cGMP-PKG-PPARγ Axis

Transient receptor potential canonical (TRPC) proteins play important roles in chronically hypoxic pulmonary hypertension (CHPH). Previous results indicated that sildenafil inhibited TRPC1 and TRPC6 expression in rat distal pulmonary arteries (PAs). However, the underlying mechanisms remain unknown....

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Detaylı Bibliyografya
Asıl Yazarlar: Wang, Jian, Yang, Kai, Xu, Lei, Zhang, Yi, Lai, Ning, Jiang, Hua, Zhang, Yajie, Zhong, Nanshan, Ran, Pixin, Lu, Wenju
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Thoracic Society 2013
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824028/
https://ncbi.nlm.nih.gov/pubmed/23526219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0185OC
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