Sildenafil Inhibits Hypoxia-Induced Transient Receptor Potential Canonical Protein Expression in Pulmonary Arterial Smooth Muscle via cGMP-PKG-PPARγ Axis

Transient receptor potential canonical (TRPC) proteins play important roles in chronically hypoxic pulmonary hypertension (CHPH). Previous results indicated that sildenafil inhibited TRPC1 and TRPC6 expression in rat distal pulmonary arteries (PAs). However, the underlying mechanisms remain unknown....

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Detalhes bibliográficos
Main Authors: Wang, Jian, Yang, Kai, Xu, Lei, Zhang, Yi, Lai, Ning, Jiang, Hua, Zhang, Yajie, Zhong, Nanshan, Ran, Pixin, Lu, Wenju
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824028/
https://ncbi.nlm.nih.gov/pubmed/23526219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0185OC
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