Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy

Impaired or deficient autophagy is believed to cause or contribute to aging, as well as a number of age-related pathologies. The exact mechanism through which alterations in autophagy induce these various pathologies is not well understood. Here we describe the creation of two in vivo mouse models t...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Wu, J. Julie, Quijano, Celia, Chen, Edmund, Liu, Hongjun, Cao, Liu, Fergusson, Maria M., Rovira, Ilsa I., Gutkind, Sarah, Daniels, Mathew P., Komatsu, Masaaki, Finkel, Toren
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Impact Journals LLC 2009
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806022/
https://ncbi.nlm.nih.gov/pubmed/20157526
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