Reciprocal regulation of acetyl-CoA carboxylase 1 and senescence in human fibroblasts involves oxidant mediated p38 MAPK activation

We sought to explore the fate of the fatty acid synthesis pathway in human fibroblasts exposed to DNA damaging agents capable of inducing senescence, a state of irreversible growth arrest. Induction of premature senescence by doxorubicin or hydrogen peroxide led to a decrease in protein and mRNA lev...

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Detaylı Bibliyografya
Yayımlandı:Arch Biochem Biophys
Asıl Yazarlar: Marmisolle, Inés, Martínez, Jennyfer, Liu, Jie, Mastrogiovanni, Mauricio, Fergusson, María M., Rovira, Ilsa I., Castro, Laura, Trostchansky, Andrés, Moreno, María, Cao, Liu, Finkel, Toren, Quijano, Celia
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5178977/
https://ncbi.nlm.nih.gov/pubmed/27983949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2016.10.016
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