Reciprocal regulation of acetyl-CoA carboxylase 1 and senescence in human fibroblasts involves oxidant mediated p38 MAPK activation

We sought to explore the fate of the fatty acid synthesis pathway in human fibroblasts exposed to DNA damaging agents capable of inducing senescence, a state of irreversible growth arrest. Induction of premature senescence by doxorubicin or hydrogen peroxide led to a decrease in protein and mRNA lev...

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Detalhes bibliográficos
Publicado no:Arch Biochem Biophys
Main Authors: Marmisolle, Inés, Martínez, Jennyfer, Liu, Jie, Mastrogiovanni, Mauricio, Fergusson, María M., Rovira, Ilsa I., Castro, Laura, Trostchansky, Andrés, Moreno, María, Cao, Liu, Finkel, Toren, Quijano, Celia
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5178977/
https://ncbi.nlm.nih.gov/pubmed/27983949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2016.10.016
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