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Acetyl-CoA Carboxylase Regulates Global Histone Acetylation
Histone acetylation depends on intermediary metabolism for supplying acetyl-CoA in the nucleocytosolic compartment. However, because nucleocytosolic acetyl-CoA is also used for de novo synthesis of fatty acids, histone acetylation and synthesis of fatty acids compete for the same acetyl-CoA pool. Th...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Biochemistry and Molecular Biology
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3390662/ https://ncbi.nlm.nih.gov/pubmed/22580297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.380519 |
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