Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy

Impaired or deficient autophagy is believed to cause or contribute to aging, as well as a number of age-related pathologies. The exact mechanism through which alterations in autophagy induce these various pathologies is not well understood. Here we describe the creation of two in vivo mouse models t...

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Main Authors: Wu, J. Julie, Quijano, Celia, Chen, Edmund, Liu, Hongjun, Cao, Liu, Fergusson, Maria M., Rovira, Ilsa I., Gutkind, Sarah, Daniels, Mathew P., Komatsu, Masaaki, Finkel, Toren
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806022/
https://ncbi.nlm.nih.gov/pubmed/20157526
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