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Purification, crystallization and preliminary X-ray analysis of Enterococcus casseliflavus aminoglycoside-2′′-phosphotransferase-IVa

The deactivation of aminoglycoside antibiotics by chemical modification is one of the major sources of bacterial resistance to this family of therapeutic compounds, which includes the clinically relevant drugs streptomycin, kanamycin and gentamicin. The aminoglycoside phosphotransferases (APHs) form...

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Detalles Bibliográficos
Main Authors: Toth, Marta, Vakulenko, Sergei, Smith, Clyde A.
Formato: Artigo
Idioma:Inglês
Publicado: International Union of Crystallography 2009
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805544/
https://ncbi.nlm.nih.gov/pubmed/20057078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309109050039
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