Purification, crystallization and preliminary X-ray analysis of Enterococcus faecium aminoglycoside-2′′-phosphotransferase-Ib [APH(2′′)-Ib]

Bacterial resistance to the aminoglycoside antibiotics is primarily the result of deactivation of the drugs. Three families of enzymes are responsible for this activity, with one such family being the aminoglycoside phosphotransferases (APHs). The gene encoding one of these enzymes, APH(2′′)-Ib, has...

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Bibliografiska uppgifter
Huvudupphovsmän: Walanj, Rupa, Young, Paul, Baker, Heather M., Baker, Edward N., Metcalf, Peter, Chow, Joseph W., Lerner, Stephen, Vakulenko, Sergei, Smith, Clyde A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: International Union of Crystallography 2005
Ämnen:
Crystallization Communications
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952440/
https://ncbi.nlm.nih.gov/pubmed/16511055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S174430910500775X
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