Purification, crystallization and preliminary X-ray analysis of Enterococcus faecium aminoglycoside-2′′-phosphotransferase-Ib [APH(2′′)-Ib]

Bacterial resistance to the aminoglycoside antibiotics is primarily the result of deactivation of the drugs. Three families of enzymes are responsible for this activity, with one such family being the aminoglycoside phosphotransferases (APHs). The gene encoding one of these enzymes, APH(2′′)-Ib, has...

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Detalhes bibliográficos
Main Authors: Walanj, Rupa, Young, Paul, Baker, Heather M., Baker, Edward N., Metcalf, Peter, Chow, Joseph W., Lerner, Stephen, Vakulenko, Sergei, Smith, Clyde A.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2005
Assuntos:
Crystallization Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952440/
https://ncbi.nlm.nih.gov/pubmed/16511055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S174430910500775X
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