Purification, crystallization and preliminary X-ray analysis of Enterococcus faecium aminoglycoside-2′′-phosphotransferase-Ib [APH(2′′)-Ib]

Bacterial resistance to the aminoglycoside antibiotics is primarily the result of deactivation of the drugs. Three families of enzymes are responsible for this activity, with one such family being the aminoglycoside phosphotransferases (APHs). The gene encoding one of these enzymes, APH(2′′)-Ib, has...

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Bibliographic Details
Main Authors: Walanj, Rupa, Young, Paul, Baker, Heather M., Baker, Edward N., Metcalf, Peter, Chow, Joseph W., Lerner, Stephen, Vakulenko, Sergei, Smith, Clyde A.
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2005
Subjects:
Crystallization Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952440/
https://ncbi.nlm.nih.gov/pubmed/16511055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S174430910500775X
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