The Crystal Structures of Substrate and Nucleotide Complexes of Enterococcus faecium Aminoglycoside-2′′-Phosphotransferase-IIa [APH(2′′)-IIa] Provide Insights into Substrate Selectivity in the APH(2′′) Subfamily

Aminoglycoside-2′′-phosphotransferase-IIa [APH(2′′)-IIa] is one of a number of homologous bacterial enzymes responsible for the deactivation of the aminoglycoside family of antibiotics and is thus a major component in bacterial resistance to these compounds. APH(2′′)-IIa produces resistance to sever...

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Bibliografiske detaljer
Main Authors: Young, Paul G., Walanj, Rupa, Lakshmi, Vendula, Byrnes, Laura J., Metcalf, Peter, Baker, Edward N., Vakulenko, Sergei B., Smith, Clyde A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698469/
https://ncbi.nlm.nih.gov/pubmed/19429619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00149-09
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