A Mitochondria-Targeted Triphenylphosphonium-Conjugated Nitroxide Functions as a Radioprotector/Mitigator

Removal of excessive mitochondrial reactive oxygen species by electron scavengers and antioxidants is a promising therapeutic strategy to reduce the detrimental effects of radiation exposure. Here we exploited triphenylphosphonium (TPP) cation as a means to target nitroxide radicals to mitochondria....

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Détails bibliographiques
Auteurs principaux: Jiang, Jianfei, Stoyanovsky, Detcho A., Belikova, Natalia A., Tyurina, Yulia Y., Zhao, Qing, Tungekar, Muhammad A., Kapralova, Valentyna, Huang, Zhentai, Mintz, Arlan H., Greenberger, Joel S., Kagan, Valerian E.
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804962/
https://ncbi.nlm.nih.gov/pubmed/19929417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR1729.1
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