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The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics
Crystallographic analysis revealed that the 17-member polyketide antibiotic lankacidin produced by Streptomyces rochei binds at the peptidyl transferase center of the eubacterial large ribosomal subunit. Biochemical and functional studies verified this finding and showed interference with peptide bo...
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| Glavni autori: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2010
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2804743/ https://ncbi.nlm.nih.gov/pubmed/20080686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914100107 |
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