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Structural basis for cross-resistance to ribosomal PTC antibiotics
Clinically relevant antibiotics that target the ribosomal peptidyl transferase center (PTC), a highly conserved ribosomal region, exert their inhibitory action by exploiting the flexibility of PTC nucleotides, which trigger modulations of the shape of the antibiotic binding pocket. Resistance to the...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2605634/ https://ncbi.nlm.nih.gov/pubmed/19098107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810826105 |
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