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Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity

New insights into functional flexibility at the peptidyl transferase center (PTC) and its vicinity were obtained by analysis of pleuromutilins binding modes to the ribosome. The crystal structures of Deinococcus radiodurans large ribosomal subunit complexed with each of three pleuromutilin derivativ...

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Detalhes bibliográficos
Main Authors: Davidovich, Chen, Bashan, Anat, Auerbach-Nevo, Tamar, Yaggie, Rachel D., Gontarek, Richard R., Yonath, Ada
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1817833/
https://ncbi.nlm.nih.gov/pubmed/17360517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700041104
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