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Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity
New insights into functional flexibility at the peptidyl transferase center (PTC) and its vicinity were obtained by analysis of pleuromutilins binding modes to the ribosome. The crystal structures of Deinococcus radiodurans large ribosomal subunit complexed with each of three pleuromutilin derivativ...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1817833/ https://ncbi.nlm.nih.gov/pubmed/17360517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700041104 |
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