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The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics
Crystallographic analysis revealed that the 17-member polyketide antibiotic lankacidin produced by Streptomyces rochei binds at the peptidyl transferase center of the eubacterial large ribosomal subunit. Biochemical and functional studies verified this finding and showed interference with peptide bo...
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| Main Authors: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2804743/ https://ncbi.nlm.nih.gov/pubmed/20080686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914100107 |
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