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Structural basis for cross-resistance to ribosomal PTC antibiotics

Clinically relevant antibiotics that target the ribosomal peptidyl transferase center (PTC), a highly conserved ribosomal region, exert their inhibitory action by exploiting the flexibility of PTC nucleotides, which trigger modulations of the shape of the antibiotic binding pocket. Resistance to the...

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Hlavní autoři: Davidovich, Chen, Bashan, Anat, Yonath, Ada
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605634/
https://ncbi.nlm.nih.gov/pubmed/19098107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810826105
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