Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells

Farnesyltransferase inhibitors (FTIs) represent a new class of anticancer drugs that show promise in blocking the growth of tumors. Here, we report that FTIs are capable of inducing apoptosis of transformed but not untransformed cells. Treatment of v-K-ras-transformed normal rat kidney (KNRK) cells...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Suzuki, Nobutaka, Urano, Jun, Tamanoi, Fuyuhiko
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1998
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC28047/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9860973/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.26.15356
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