Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells
Farnesyltransferase inhibitors (FTIs) represent a new class of anticancer drugs that show promise in blocking the growth of tumors. Here, we report that FTIs are capable of inducing apoptosis of transformed but not untransformed cells. Treatment of v-K-ras-transformed normal rat kidney (KNRK) cells...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC28047/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9860973/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.26.15356 |
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