Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells

Farnesyltransferase inhibitors (FTIs) represent a new class of anticancer drugs that show promise in blocking the growth of tumors. Here, we report that FTIs are capable of inducing apoptosis of transformed but not untransformed cells. Treatment of v-K-ras-transformed normal rat kidney (KNRK) cells...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Suzuki, Nobutaka, Urano, Jun, Tamanoi, Fuyuhiko
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1998
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC28047/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9860973/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.26.15356
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