Keratin 18 attenuates estrogen receptor α-mediated signaling by sequestering LRP16 in cytoplasm

BACKGROUND: Oncogenesis in breast cancer is often associated with excess estrogen receptor α(ERα) activation and overexpression of its coactivators. LRP16 is both an ERα target gene and an ERα coactivator, and plays a crucial role in ERα activation and proliferation of MCF-7 breast cancer cells. How...

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Detalhes bibliográficos
Main Authors: Meng, Yuanguang, Wu, Zhiqiang, Yin, Xiaoyun, Zhao, Yali, Chen, Meixia, Si, Yiling, Yang, Jie, Fu, Xiaobing, Han, Weidong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
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Research article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804594/
https://ncbi.nlm.nih.gov/pubmed/20035625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-10-96
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