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Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX
MDM2 and MDMX function as key regulators of p53 by binding to its N terminus, inhibiting its transcriptional activity, and promoting degradation. MDM2 and MDMX overexpression or hyperactivation directly contributes to the loss of p53 function during the development of nearly 50% of human cancers. Re...
Gorde:
| Egile Nagusiak: | , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Society for Biochemistry and Molecular Biology
2010
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2804373/ https://ncbi.nlm.nih.gov/pubmed/19910468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.073056 |
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