Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX

MDM2 and MDMX function as key regulators of p53 by binding to its N terminus, inhibiting its transcriptional activity, and promoting degradation. MDM2 and MDMX overexpression or hyperactivation directly contributes to the loss of p53 function during the development of nearly 50% of human cancers. Re...

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Bibliographische Detailangaben
Hauptverfasser: Phan, Jason, Li, Zhenyu, Kasprzak, Agnieszka, Li, Baozong, Sebti, Said, Guida, Wayne, Schönbrunn, Ernst, Chen, Jiandong
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804373/
https://ncbi.nlm.nih.gov/pubmed/19910468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.073056
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