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Roscovitine Binds to Novel L-channel (Ca(V)1.2) Sites That Separately Affect Activation and Inactivation
L-type (Ca(V)1.2) calcium channel antagonists play an important role in the treatment of cardiovascular disease. (R)-Roscovitine, a trisubstituted purine, has been shown to inhibit L-currents by slowing activation and enhancing inactivation. This study utilized molecular and pharmacological approach...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2804190/ https://ncbi.nlm.nih.gov/pubmed/19887376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.076448 |
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