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Roscovitine, a cyclin-dependent kinase inhibitor, affects several gating mechanisms to inhibit cardiac L-type (Ca((V))1.2) calcium channels
BACKGROUND AND PURPOSE: L-type calcium channels (Ca ((V))1.2) play an important role in cardiac contraction. Roscovitine, a cyclin-dependent kinase inhibitor and promising anticancer drug, has been shown to affect Ca ((V))1.2 by inhibiting current amplitude and slowing activation. This research inve...
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| Glavni autori: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2007
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2042960/ https://ncbi.nlm.nih.gov/pubmed/17700718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707414 |
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