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Roscovitine Inhibits Ca(V)3.1 (T-Type) Channels by Preferentially Affecting Closed-State Inactivation
T-type calcium channels (Ca(V)3) play an important role in many physiological and pathological processes, including cancerogenesis. Ca(V)3 channel blockers have been proposed as potential cancer treatments. Roscovitine, a trisubstituted purine, is a cyclin-dependent kinase (CDK) inhibitor that is cu...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3263959/ https://ncbi.nlm.nih.gov/pubmed/22088954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.187104 |
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