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Nucleotide Excision Repair of a DNA Interstrand Cross-Link Produces Single and Double Strand Breaks

The DNA radical resulting from formal hydrogen atom abstraction from the thymidine methyl group, 5-(2′-deoxyuridinyl)methyl radical, forms interstrand cross-links with the opposing 2′-deoxyadenosine. This is the first chemically characterized, radical mediated cross-link between two opposing nucleot...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Peng, Xiaohua, Ghosh, Avik K., Van Houten, Bennett, Greenberg, Marc M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804059/
https://ncbi.nlm.nih.gov/pubmed/20000382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901603h
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