Carregant...

X-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide Hydrolase

Three cocrystal X-ray structures of the α-ketoheterocycle inhibitors 3–5 bound to a humanized variant of fatty acid amide hydrolase (FAAH) are disclosed and comparatively discussed alongside those of 1 (OL-135) and its isomer 2. These five X-ray structures systematically probe each of the three acti...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Mileni, Mauro, Garfunkle, Joie, Ezzili, Cyrine, Kimball, F. Scott, Cravatt, Benjamin F., Stevens, Raymond C., Boger, Dale L.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804032/
https://ncbi.nlm.nih.gov/pubmed/19924997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9012196
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!