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A High Throughput Serum Paraoxonase Assay for Discovery of Small Molecule Modulators of PON1 Activity

PON1 has been demonstrated to be the serum enzyme responsible for detoxifying organophosphate chemical weapons and plays a protective role against atherosclerosis. In order to identify small molecules that modulate PON1 activity in serum, we developed a high throughput kinetic absorbance assay using...

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Detalhes bibliográficos
Main Authors: Graves, Tiffany L, Scott, John E
Formato: Artigo
Idioma:Inglês
Publicado em: Bentham Open 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803440/
https://ncbi.nlm.nih.gov/pubmed/20161844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1875397300802010051
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