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Computational design and experimental study of tighter binding peptides to an inactivated mutant of HIV-1 protease

Drug resistance in HIV-1 protease, a barrier to effective treatment, is generally caused by mutations in the enzyme that disrupt inhibitor binding but still allow for substrate processing. Structural studies with mutant, inactive enzyme, have provided detailed information regarding how the substrate...

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Autores principales: Altman, Michael D., Nalivaika, Ellen A., Prabu-Jeyabalan, Moses, Schiffer, Celia A., Tidor, Bruce
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802840/
https://ncbi.nlm.nih.gov/pubmed/17729291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.21514
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