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Computational design and experimental study of tighter binding peptides to an inactivated mutant of HIV-1 protease
Drug resistance in HIV-1 protease, a barrier to effective treatment, is generally caused by mutations in the enzyme that disrupt inhibitor binding but still allow for substrate processing. Structural studies with mutant, inactive enzyme, have provided detailed information regarding how the substrate...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2802840/ https://ncbi.nlm.nih.gov/pubmed/17729291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.21514 |
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