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UBE2S drives elongation of K11-linked ubiquitin chains by the Anaphase-Promoting Complex

The Anaphase-Promoting Complex (APC) is an E3 ubiquitin ligase that regulates mitosis and G1 by sequentially targeting cell-cycle regulators for ubiquitination and proteasomal degradation. The mechanism of ubiquitin chain formation by APC and the resultant chain topology remains controversial. By us...

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Библиографические подробности
Главные авторы: Wu, Tao, Merbl, Yifat, Huo, Ying, Gallop, Jennifer L., Tzur, Amit, Kirschner, Marc W.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802591/
https://ncbi.nlm.nih.gov/pubmed/20080579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912802107
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