Transport of the Photodynamic Therapy Agent 5-Aminolevulinic Acid by Distinct H(+)-Coupled Nutrient Carriers Coexpressed in the Small Intestine

5-Aminolevulinic acid (ALA) is a prodrug used in photodynamic therapy, fluorescent diagnosis, and fluorescent-guided resection because it leads to accumulation of the photosensitizer protoporphyrin IX (PpIX) in tumor tissues. ALA has good oral bioavailability, but high oral doses are required to obt...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Anderson, Catriona M. H., Jevons, Mark, Thangaraju, Muthusamy, Edwards, Noel, Conlon, Nichola J., Woods, Steven, Ganapathy, Vadivel, Thwaites, David T.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The American Society for Pharmacology and Experimental Therapeutics 2010
Θέματα:
Metabolism, Transport, and Pharmacogenomics
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802479/
https://ncbi.nlm.nih.gov/pubmed/19789362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.159822
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