Transport of the Photodynamic Therapy Agent 5-Aminolevulinic Acid by Distinct H(+)-Coupled Nutrient Carriers Coexpressed in the Small Intestine

5-Aminolevulinic acid (ALA) is a prodrug used in photodynamic therapy, fluorescent diagnosis, and fluorescent-guided resection because it leads to accumulation of the photosensitizer protoporphyrin IX (PpIX) in tumor tissues. ALA has good oral bioavailability, but high oral doses are required to obt...

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Главные авторы: Anderson, Catriona M. H., Jevons, Mark, Thangaraju, Muthusamy, Edwards, Noel, Conlon, Nichola J., Woods, Steven, Ganapathy, Vadivel, Thwaites, David T.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2010
Предметы:
Metabolism, Transport, and Pharmacogenomics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802479/
https://ncbi.nlm.nih.gov/pubmed/19789362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.159822
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