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pH-Dependent Association of Proteins. The Test Case of Monoclonal Antibody HyHEL-5 and its Antigen Hen Egg White Lysozyme
We describe a method for determining diffusion-controlled rate constants for protein-protein association that explicitly includes the solution pH. The method combines the transient-complex theory for computing electrostatically enhanced association rates with an approach based on a rigorous thermody...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2802180/ https://ncbi.nlm.nih.gov/pubmed/19883097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp906829z |
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