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Modeling the Binding Sites of Anti-Hen Egg White Lysozyme Antibodies HyHEL-8 and HyHEL-26: An Insight into the Molecular Basis of Antibody Cross-Reactivity and Specificity

Three antibodies, HyHEL-8 (HH8), HyHEL-10 (HH10), and HyHEL-26 (HH26) are specific for the same epitope on hen egg white lysozyme (HEL), and share >90% sequence homology. Their affinities vary by several orders of magnitude, and among the three antibodies, HH8 is the most cross-reactive with kine...

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Bibliographic Details
Main Authors: Mohan, S., Sinha, Neeti, Smith-Gill, Sandra J.
Format: Artigo
Language:Inglês
Published: Biophysical Society 2003
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303598/
https://ncbi.nlm.nih.gov/pubmed/14581222
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