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Binding of Natural and Synthetic Polyphenols to Human Dihydrofolate Reductase

Dihydrofolate reductase (DHFR) is the subject of intensive investigation since it appears to be the primary target enzyme for antifolate drugs. Fluorescence quenching experiments show that the ester bond-containing tea polyphenols (-)-epigallocatechin gallate (EGCG) and (-)-epicatechin gallate (ECG)...

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Bibliografiske detaljer
Main Authors: Sánchez-del-Campo, Luís, Sáez-Ayala, Magalí, Chazarra, Soledad, Cabezas-Herrera, Juan, Rodríguez-López, José Neptuno
Format: Artigo
Sprog:Inglês
Udgivet: Molecular Diversity Preservation International (MDPI) 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802001/
https://ncbi.nlm.nih.gov/pubmed/20054477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms10125398
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