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Binding of Natural and Synthetic Polyphenols to Human Dihydrofolate Reductase

Dihydrofolate reductase (DHFR) is the subject of intensive investigation since it appears to be the primary target enzyme for antifolate drugs. Fluorescence quenching experiments show that the ester bond-containing tea polyphenols (-)-epigallocatechin gallate (EGCG) and (-)-epicatechin gallate (ECG)...

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Bibliografiska uppgifter
Huvudupphovsmän: Sánchez-del-Campo, Luís, Sáez-Ayala, Magalí, Chazarra, Soledad, Cabezas-Herrera, Juan, Rodríguez-López, José Neptuno
Materialtyp: Artigo
Språk:Inglês
Publicerad: Molecular Diversity Preservation International (MDPI) 2009
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802001/
https://ncbi.nlm.nih.gov/pubmed/20054477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms10125398
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