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Binding of Natural and Synthetic Polyphenols to Human Dihydrofolate Reductase
Dihydrofolate reductase (DHFR) is the subject of intensive investigation since it appears to be the primary target enzyme for antifolate drugs. Fluorescence quenching experiments show that the ester bond-containing tea polyphenols (-)-epigallocatechin gallate (EGCG) and (-)-epicatechin gallate (ECG)...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Molecular Diversity Preservation International (MDPI)
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2802001/ https://ncbi.nlm.nih.gov/pubmed/20054477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms10125398 |
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