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The First N-terminal Amino Acids of α-Synuclein Are Essential for α-Helical Structure Formation In Vitro and Membrane Binding in Yeast

α-Synuclein (α-syn), a protein implicated in Parkinson’s disease, is structurally diverse. In addition to its random-coil state, α-syn can adopt an α-helical structure upon lipid membrane binding or a β-sheet structure upon aggregation. We used yeast biology and in vitro biochemistry to detect how s...

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Main Authors: Vamvaca, Katherina, Volles, Michael J., Lansbury, Peter T.
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801807/
https://ncbi.nlm.nih.gov/pubmed/19285989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.03.021
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