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The First N-terminal Amino Acids of α-Synuclein Are Essential for α-Helical Structure Formation In Vitro and Membrane Binding in Yeast
α-Synuclein (α-syn), a protein implicated in Parkinson’s disease, is structurally diverse. In addition to its random-coil state, α-syn can adopt an α-helical structure upon lipid membrane binding or a β-sheet structure upon aggregation. We used yeast biology and in vitro biochemistry to detect how s...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2801807/ https://ncbi.nlm.nih.gov/pubmed/19285989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.03.021 |
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