c-Jun Regulates Phosphoinositide-dependent Kinase 1 Transcription: IMPLICATION FOR Akt AND PROTEIN KINASE C ACTIVITIES AND MELANOMA TUMORIGENESIS

Mutations in N-RAS and B-RAF, which commonly occur in melanomas, result in constitutive activation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated protein kinase (ERK) signaling. Active ERK increases expression and activity of the c-Jun transcription factor, linking ERK...

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Bibliographic Details
Main Authors: Lopez-Bergami, Pablo, Kim, Hyungsoo, Dewing, Antimone, Goydos, James, Aaronson, Stuart, Ronai, Ze'ev
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801291/
https://ncbi.nlm.nih.gov/pubmed/19910471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.075630
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