BI-69A11-mediated inhibition of AKT leads to effective regression of xenograft melanoma

The AKT/PKB pathway plays a central role in tumor development and progression and is often up-regulated in different tumor types, including melanomas. We have recently reported on the in silico approach to identify putative inhibitors for AKT/PKB. Of the reported hits, we selected BI-69A11, a compou...

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Detalhes bibliográficos
Main Authors: Gaitonde, Supriya, De, Surya K, Tcherpakov, Marianna, Dewing, Antimone, Yuan, Hongbin, Riel-Mehan, Megan, Krajewski, Stan, Robertson, Gavin, Pellecchia, Maurizio, Ronai, Ze’ev
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860277/
https://ncbi.nlm.nih.gov/pubmed/19175524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1755-148X.2009.00544.x
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