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p53 Binding to Nucleosomal DNA Depends on the Rotational Positioning of DNA Response Element
The sequence-specific binding to DNA is crucial for the p53 tumor suppressor function. To investigate the constraints imposed on p53-DNA recognition by nucleosomal organization, we studied binding of the p53 DNA binding domain (p53DBD) and full-length wild-type p53 protein to a single p53 response e...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2801259/ https://ncbi.nlm.nih.gov/pubmed/19887449 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.081182 |
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