p53 Binding to Nucleosomal DNA Depends on the Rotational Positioning of DNA Response Element

The sequence-specific binding to DNA is crucial for the p53 tumor suppressor function. To investigate the constraints imposed on p53-DNA recognition by nucleosomal organization, we studied binding of the p53 DNA binding domain (p53DBD) and full-length wild-type p53 protein to a single p53 response e...

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Detalhes bibliográficos
Main Authors: Sahu, Geetaram, Wang, Difei, Chen, Claudia B., Zhurkin, Victor B., Harrington, Rodney E., Appella, Ettore, Hager, Gordon L., Nagaich, Akhilesh K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Transcription, Chromatin, and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801259/
https://ncbi.nlm.nih.gov/pubmed/19887449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.081182
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