Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents

For the past 15–20 years, the intracellular delivery and silencing activity of oligodeoxynucleotides have been essentially completely dependent on the use of a delivery technology (e.g. lipofection). We have developed a method (called ‘gymnosis’) that does not require the use of any transfection rea...

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Bibliographic Details
Main Authors: Stein, C. A., Hansen, J. Bo, Lai, Johnathan, Wu, SiJian, Voskresenskiy, Anatoliy, Høg, Anja, Worm, Jesper, Hedtjärn, Maj, Souleimanian, Naira, Miller, Paul, Soifer, Harris S., Castanotto, Daniella, Benimetskaya, Luba, Ørum, Henrik, Koch, Troels
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Methods Online
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2800216/
https://ncbi.nlm.nih.gov/pubmed/19854938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp841
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