DNA adducts of aristolochic acid II: total synthesis and site-specific mutagenesis studies in mammalian cells

Aristolochic acids I and II (AA-I, AA-II) are found in all Aristolochia species. Ingestion of these acids either in the form of herbal remedies or as contaminated wheat flour causes a dose-dependent chronic kidney failure characterized by renal tubulointerstitial fibrosis. In ∼50% of these cases, th...

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Autori principali: Attaluri, Sivaprasad, Bonala, Radha R., Yang, In-Young, Lukin, Mark A., Wen, Yujing, Grollman, Arthur P., Moriya, Masaaki, Iden, Charles R., Johnson, Francis
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2010
Soggetti:
Synthetic Biology and Chemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2800210/
https://ncbi.nlm.nih.gov/pubmed/19854934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp815
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