Bioactivation of the human carcinogen aristolochic acid

Aristolochic acids are potent human carcinogens; the role of phase II metabolism in their bioactivation is unclear. Accordingly, we tested the ability of the partially reduced metabolites, N-hydroxyaristolactams (AL-NOHs), and their N-O-sulfonated and N-O-acetylated derivatives to react with DNA to...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Sidorenko, Viktoriya S., Attaluri, Sivaprasad, Zaitseva, Irina, Iden, Charles R., Dickman, Kathleen G., Johnson, Francis, Grollman, Arthur P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
Original Manuscript
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123648/
https://ncbi.nlm.nih.gov/pubmed/24743514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgu095
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky