Bioactivation of the human carcinogen aristolochic acid

Aristolochic acids are potent human carcinogens; the role of phase II metabolism in their bioactivation is unclear. Accordingly, we tested the ability of the partially reduced metabolites, N-hydroxyaristolactams (AL-NOHs), and their N-O-sulfonated and N-O-acetylated derivatives to react with DNA to...

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Detalhes bibliográficos
Main Authors: Sidorenko, Viktoriya S., Attaluri, Sivaprasad, Zaitseva, Irina, Iden, Charles R., Dickman, Kathleen G., Johnson, Francis, Grollman, Arthur P.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Original Manuscript
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123648/
https://ncbi.nlm.nih.gov/pubmed/24743514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgu095
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