Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN

Mechanisms of telomere replication remain poorly defined. It has been suggested that G-rich telomeric strand replication by lagging mechanisms requires, in a stochastic way, the WRN protein. Here we show that this requirement is more systematic than previously thought. Our data are compatible with a...

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Bibliographic Details
Main Authors: Arnoult, Nausica, Saintome, Carole, Ourliac-Garnier, Isabelle, Riou, Jean-François, Londoño-Vallejo, Arturo
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2009
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2800086/
https://ncbi.nlm.nih.gov/pubmed/20008939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.544009
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