Localization of an NH(2)-Terminal Disease-Causing Mutation Hotspot to the “Clamp” Region in the Three-Dimensional Structure of the Cardiac Ryanodine Receptor

A region between residues 414 and 466 in the cardiac ryanodine receptor (RyR2) harbors more than half of the known NH(2)-terminal mutations associated with cardiac arrhythmias and sudden death. To gain insight into the structural basis of this NH(2)-terminal mutation hotspot, we have determined its...

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Main Authors: Wang, Ruiwu, Chen, Wenqian, Cai, Shitian, Zhang, Jing, Bolstad, Jeff, Wagenknecht, Terence, Liu, Zheng, Chen, S. R. Wayne
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2800043/
https://ncbi.nlm.nih.gov/pubmed/17452324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M700660200
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