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Localization of an NH(2)-Terminal Disease-Causing Mutation Hotspot to the “Clamp” Region in the Three-Dimensional Structure of the Cardiac Ryanodine Receptor
A region between residues 414 and 466 in the cardiac ryanodine receptor (RyR2) harbors more than half of the known NH(2)-terminal mutations associated with cardiac arrhythmias and sudden death. To gain insight into the structural basis of this NH(2)-terminal mutation hotspot, we have determined its...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2800043/ https://ncbi.nlm.nih.gov/pubmed/17452324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M700660200 |
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